Overview of criteria and their definitions that are most used by different organisations
to identify substances of concern

logo_table_criteria

 

Table 1: HEALTH HAZARDS

Table 2: ENVIRONMENTAL EFFECTS

Table 3: FIRE AND EXPLOSION HAZARDS

Print Version

 

LEGEND FOR TABLES 1 - 3:

CM

Column Model, IFA (Germany)

QS

Quick Scan, VROM (Netherlands)

PRI

PRIO, KEMI (Sweden)

SIN

SIN LIST, ChemSec (Sweden)

IST

ISTAS Black list, ISTAS (Spain)

TU

Trade Union List, European Trade Union Confederation (ETUC)

NT

NTP 712 INSHT, National Institute for Health and Safety at Work (Spain)

COS

COSHH Essentials, Health and Safety Executive (UK)

Mal

MAL code system

NP

National Plan to implement Stockholm Convention and Regulation 850/2004, on Persistent Organic Pollutants, Ministry of Environment (Spain)

R

REACH Regulation, European Union

CC

Cradle to Cradle Design Protocol, MBDC (USA, Germany)

TUR

Five Chemicals Alternatives Assessment Study, TURI (USA)

DfE

Design for the Environment Formulator Program, EPA (USA)

GS

Green Screen for Safer Chemicals, Clean Production Action (Canada, US)

SJ

SC Johnson Greenlist

X

Hazard criteria

•

The most used definitions for the criteria

 

 

 

 

Table 1: HEALTH HAZARDS

 

Hazard criteria

Criteria and definition

Source of criteria

European

Non-European

CM

QS

PRI

SIN

IST

TU

NT

COS

Mal

NP

R

CC

TUR

DfE

GS

SJ

ACUTE TOXICITY

Highly toxic

Highly toxic defined as below:

X

X

X

 

X

 

X

 

X

 

 

X

 

X

X

X

Very toxic by inhalation (R26 / H330)

Very toxic by skin contact (R27 / H310)

Very toxic by swallowing (R28 / H300)

•

•

•

 

•

 

•

 

•

 

 

 

 

 

 

 

Combinations of these phrases

 

 

 

 

•

 

 

 

•

 

 

 

 

 

 

 

Combinations of these phrases with R39 / H370

 

•

•

 

•

 

 

 

•

 

 

 

 

 

 

 

Contact with acids liberates very toxic gas (R32 / EUH032)

•

•

 

 

•

 

•

 

 

 

 

 

 

 

 

 

Toxic, or danger of very serious irreversible effects through inhalation

(R23 / H330), in contact with skin (R24 / H331) or if swallowed (R25 / H301)

 

•

 

 

 

 

•

 

•

 

 

 

 

 

 

 

Contact with water or acids liberates very toxic gas (R29 / EUH029, R31 / EUH031, R32 / EUH032)

•

•

 

 

•

 

•

 

 

 

 

 

 

 

 

 

Vapors may cause drowsiness or dizziness (R67 / H336)

 

•

 

 

 

 

•

 

•

 

 

 

 

 

 

 

Repeated exposure may cause skin dryness or cracking (R66 / EUH066)

 

 

 

 

 

 

•

 

 

 

 

 

 

 

 

 

GHS Acute toxicity Category 1 or 2

 

 

 

 

 

 

 

 

 

 

 

 

 

•

•

 

Corrosion/

irritation of skin/eyes

Corrosion/irritation of skin/eyes defined as below:

X

X

 

 

 

 

 

 

X

 

 

X

 

X

X

X

Causes (severe) burns (R34 / H314, R35 / H314)

•

•

 

 

 

 

 

 

•

 

 

 

 

 

 

 

• Evidence of irreversible effects in studies of human populations;

• Weight of evidence of irreversible effects in animal studies; or

• GHS Category 1 (skin or eye)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

•

 

 

CM

QS

PRI

SIN

IST

TU

NT

COS

Mal

NP

R

CC

TUR

DfE

GS

SJ

CHRONIC TOXICITY

Highly toxic

Highly toxic defined as below:

X

X

X

X

X

X

X

X

X

X

 

X

 

X

 

 

Danger of severe damage to health by prolonged exposure:

 R48/23, R48/24, R48/25 and combinations / H372

•

•

•

 

•

 

 

 

 

 

 

 

 

 

 

 

Danger of cumulative effects R33 / H373

•

 

 

 

•

 

•

 

 

 

 

 

 

 

 

 

Carcinogenicity

Carcinogenicity defined as below:

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

EU Category 1 or 2 (R45 / H530, R49 / H530i)

•

•

•

•

•

•

•

•

•

 

•

 

 

 

•

 

EU Category 3 (R40 / H531)

•

•

 

 

•

•

•

 

 

 

 

 

 

 

 

 

German classification K1, K2

•

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

IARC 1 & 2A

 

 

 

 

•

•

 

 

 

 

 

 

•

•

•

•

IARC 2B

 

 

 

 

•

•

 

 

 

 

 

 

 

•

 

 

US EPA known/likely (probable)

 

 

 

 

 

 

 

 

 

 

 

 

•

•

•

 

• Evidence of adverse effects in humans; • Weight of evidence demonstrates potential for adverse effects in humans; • NTP known or reasonably anticipated to be human carcinogen; • OSHA carcinogen; • California Prop 65; or • GHS Category 1 A or B* 

 

 

 

 

 

 

 

 

 

 

 

 

 

•

•

•

Mutagenicity/ genotoxicity

Mutagenicity/genotoxicity desrcibed as below:

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

 

EU Category 1 or 2 (R46 / H340)

•

•

•

•

•

•

•

•

•

 

•

 

•

 

•

 

EU Category 3 (R68 / H341)

•

 

•

 

•

•

•

•

 

 

 

 

 

 

 

 

• Evidence of adverse effects in humans;• Weight of evidence demonstrates potential for adverse effects in humans; • GHS Category 1 A or B*

 

 

 

 

 

 

 

 

 

 

 

 

 

 

•

 

Reprotoxicity

(including developmental toxicology)

Reprotoxicity defined as below:

X

X

X

X

X

X

X

 

X

X

X

X

 

X

X

X

EU Category 1 or 2 (R60, R61 / H360)

•

•

•

•

•

•

•

 

•

 

•

 

 

 

•

 

EU Category 3 (R62, R63 / H361)

 

 

 

 

•

•

•

 

 

 

 

 

 

 

 

 

May cause harm to breastfed babies (R64 / H362)

 

 

 

 

•

 

•

 

 

 

 

 

 

 

 

 

• Evidence of adverse effects in humans; • Weight of evidence demonstrates potential for adverse effects in humans; • NTP Center for the Evaluation of Risks to Human Reproduction;• California Prop 65; or • GHS Category 1 A or B*

 

 

 

 

 

 

 

 

 

 

 

 

 

 

•

•

 

CM

QS

PRI

SIN

IST

TU

NT

COS

Mal

NP

R

CC

TUR

DfE

GS

SJ

Endocrine disruptors

Endocrine disruptors described as below:

 

 

X

X

X

X

X

 

 

X

X

X

 

 

X

X

EU list of known endocrine disruptors

 

 

•

•

•

•

 

 

 

 

 

 

 

 

 

 

• Evidence of adverse effects in humans;

• Weight of evidence demonstrates potential for adverse effects in humans;

 

 

 

 

 

 

 

 

 

 

•

 

 

 

•

 

Sensitization of the skin or respiratory system

Sensitization of the skin or respiratory system described as below:

X

X

 

 

X

X

X

X

X

X

 

X

 

X

X

X

• May cause sensitization by inhalation (R42 / H317)

• May cause sensitization by skin contact (R43 / H334)

•

•

 

 

•

•

•

•

•

 

 

 

 

 

 

 

• Evidence of adverse effects in humans; • Weight of evidence demonstrates potential for adverse effects in humans;

• GHS Category 1 (skin or respiratory)*; or • Positive responses in predictive Human Repeat Insult Patch Test – HRIPT (skin)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

•

 

Substances included in the ‘List of REACH Allergens’

 

 

 

 

 

•

 

 

 

 

 

 

 

 

 

 

Neurotoxicity

Neurotoxicity

 

 

 

 

X

X

 

 

 

X

 

 

 

 

 

 

Permanent neurotoxic effects Provisional list for occupational neurotoxicants included in the review published by Vela et al.

 

 

 

 

•

•

 

 

 

 

 

 

 

 

 

 

Immune system effects

Immune system effects as defined below:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

X

 

• Evidence of adverse effects in humans;• Weight of evidence demonstrates potential for adverse effects in humans;

 

 

 

 

 

 

 

 

 

 

 

 

 

 

•

 

Systemic toxicity/organ effects (via single or repeated exposure

Systemic toxicity/organ effects defined as below:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

X

 

• Evidence of adverse effects in humans; • Weight of evidence demonstrates potential for adverse effects in humans; • GHS Category 1(organ/systemic toxicity following single or repeated exposure

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CM

QS

PRI

SIN

IST

TU

NT

COS

Mal

NP

R

CC

TUR

DfE

GS

SJ

 

Top

 

 

 

Table 2: ENVIRONMENTAL EFFECTS

 

Hazard criteria

Criteria and definition

Source of criteria

European

Non-European

CM

QS

PRI

SIN

IST

TU

NT

COS

Mal

NP

R

CC

TUR

DfE

GS

SJ

Persistence and/or bioaccumu-lation and toxicity

Persistence and/or bioaccumulation defined as below:

X

X

X

X

X

X

X

 

 

X

X

X

X

X

X

X

PBT (Each source uses different values)

 

•

•

•

•

•

 

 

 

 

•

 

•

 

•

 

vPvB

 

•

•

•

 

•

 

 

 

 

•

 

 

 

•

 

All substances with no data for P, B ,T

 

•

 

 

 

 

 

 

 

 

 

 

 

 

 

 

vPT or vBT

 

 

 

 

 

 

 

 

 

 

 

 

 

 

•

 

May cause long-term adverse effects in the aquatic environment (R53 / H413)

May cause long-term adverse effects in the environment (R58)

•

 

 

 

•

 

 

 

 

 

 

 

 

 

 

•

Ozone depletition

Ozone depletition as defined below:

X

 

X

 

X

 

 

 

 

 

 

X

 

X

 

X

Ozone depleting substances (R59 / EUH059)

•

 

•

 

•

 

 

 

 

 

 

 

 

 

 

•

Environmental toxicity

Environmental toxicity as defined below:

 

 

 

 

 

 

 

 

 

 

 

X

 

 

 

 

Toxic to flora (R54)

Toxic to fauna (R55)

Toxic to soil organisms (R56)

Toxic to bees (R57)

X

 

 

 

X

 

 

 

 

 

 

 

 

 

 

•

Aquatic toxicity

Aquatic toxicity as defined below:

X

 

 

 

X

 

 

 

 

X

X

X

 

X

 

X

Very toxic to aquatic organisms R50 / H400.

Toxic to aquatic organisms R51 / H410, H411.

Harmful to aquatic organisms R52 / H 412.

•

 

 

 

•

 

 

 

 

 

•

 

 

 

 

•

Water pollution classification WGK3

•

 

 

 

•

 

 

 

 

 

 

 

 

 

 

 

Carcinogens and Mutagens category 1,2; Reprotoxic category 1,2 3; T/Xn + R48, NOEC < 0,01

 

 

 

 

 

 

 

 

 

•

•

 

 

 

 

 

 

Top

 

 

 

Table 3: FIRE AND EXPLOSION HAZARDS – Many tools concentrate on hazards to health and environment and not on those to safety. These hazards are however important due to their potential for accidents.

 

Hazard criteria

Criteria and definition

Source of criteria

European

Non-European

CM

QS

PRI

SIN

IST

TU

NT

COS

Mal

NP

R

CC

TUR

DfE

GS

SJ

Explosion

Explosion as defined below:

X

 

 

 

X

 

 

 

 

 

 

 

 

 

 

 

Explosive (R2, R3 or H200/ H201/H202/ H203/H204/H205)

•

 

 

 

•

 

 

 

 

 

 

 

 

 

 

 

Flammability

Flammability as defined below:

X

 

 

 

X

 

 

 

 

 

 

 

 

 

 

 

Extremely flammable gases and liquids (R12 or H220, H221, H224, H242)

•

 

 

 

•

 

 

 

 

 

 

 

 

 

 

 

Spontaneously flammable (R17, H250)

•

 

 

 

•

 

 

 

 

 

 

 

 

 

 

 

Highly flammable substances/preparations R11 / H222, H225

•

 

 

 

•

 

 

 

 

 

 

 

 

 

 

 

Substances/preparations, liberating extremely flammable gases when in contact with water (R15)

•

 

 

 

•

 

 

 

 

 

 

 

 

 

 

 

Oxidising

Oxidising as defined below:

X

 

 

 

X

 

 

 

 

 

 

 

 

 

 

 

Oxidizing substances/preparations R7 / H242, R8 / H270, R9 / H271

•

 

 

 

•

 

 

 

 

 

 

 

 

 

 

 

Other properties

Substances/preparations with specific properties R1, R4, R5, R6, R7, R14, R16, R18, R19, R30, R44 / EUH001, EUH240, EUH006, EUH271, EUH014, EUH018, EUH019, EUH 209(A), EUH044

•

 

 

 

•

 

 

 

 

 

 

 

 

 

 

 

 

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